sorbitan monostearate toxicity

Polyoxyethylene-40-sorbitan monostearate Polysorbate 60 Sorbitan, monooctadecanoate, poly(oxy-1,2-ethanediyl) derivs. Sorbitan monostearate (Span 60) is a non-ionic surfactant with emulsifying, dispersing, and wetting properties used as a food additive, additive in mixtures for drug use and in skin care products. Then estimated as … Tween 60. Sorbitans are a group of compounds derived from sorbitol, a sugar alcohol.8 Joseph Boussin, a French chemist, first isolated sorbitol from berries in 1872.11 Notable sorbitan derivatives include sorbitan sesquioleate (SSO), sorbitan monooleate (SMO), sorbitan monostearate (SMS) and polysorbate.8 SSO is fatty acid ester formed from mono- and diesters of oleic acid and hexitol … Sorbitan monolaurate 10.6. Acute oral toxicity study of test chemical was conducted on rats at the dose concentration of 60000 mg/kg bw. Gene mutation toxicity study was performed to determine the mutagenic nature of the test chemical. Short term toxicity of test chemical were studied on the mortality of fish Oryzias latipes (Japanese Medaka). 1951 … Polyoxyethylene sorbitan monostearate - Identification, toxicity, use, water pollution potential, ecological toxicity and regulatory information: Note: See Working with the Information on this Page section below for important notes about this data. Sorbitan monostearate may be safely used as an emulsifier in the following food, sometimes together with polysorbate (60, 65, 80) (1): Whipped edible oil topping; Cakes and cake mixes, icings and fillings; Nonstandardized confectionery coatings and standardized cacao products; Edible vegetable fat-water emulsions in beverage coffee ; It can also be used as a rehydration aid in the … This stabilization effect is why sorbitan stearate is known as an emulsifier — it allows two liquids, which normally would not blend, to form a stable mix called an emulsion. In subchronic and chronic oral toxicity studies, PEGs did not cause adverse reproductive effects. Based on the mortality of fish Oryzias latipes (Japanese Medaka) by the chemical incubation for 24 and 48 hrs, the LC50 was observed at 260 mg/l and 240 mg/l. Nutritional and pathological effects of sorbitan monolaurate, polyoxyethylene sorbitan monolaurate, polyoxyethylene monolaurate, and polyoxyethylene monostearate when fed to rats. 1. It is approved for use by FDA in quantities not exceeding the amount reasonably required to accomplish the intended effect. Extensive human and animal testing have show little to no adverse health effects. Even when administered in doses much higher than those that would be ingested in an average diet or from a beauty regimen, sorbitan monostearate is safe for human and animal use. In rabbits, sorbitan monostearate was irritant when applied repeatedly to the skin. The Panel considered that the available reproductive and developmental toxicity studies with sorbitan monostearate have limitations but no adverse effects were reported. based on the data presented in that assessment, the Panel concluded that sorbitan stearate, sorbitan laurate, sorbitan sesqui-oleate, sorbitan oleate, sorbitan tristearate, sorbitan palmitate, and sorbitan trioleate were safe as cosmetic ingredients under [then] present conditions of concentration and use. Sorbitan stearate is an essential ingredient in many lotions and other skin-care products. My dough was NOT fermented at all and became really hard like soft plastic! Nutritional and pathological effects of sorbitan monolaurate, polyoxyethylene sorbitan monolaurate, polyoxyethylene monolaurate, and polyoxyethylene monostearate when fed to rats Arch Biochem Biophys. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Since the fatty acids used in the production of cosmetic ingredients frequently contain fatty acids other than the principal acid named (ie, a mixture), each of the polysorbates may contain a complex mixture of fatty acid moieties.1,26 Table A 13-week oral repeated-dose toxicity study with CASRN 1338-39-2 in rats showed decreased body weight and significantly increased relative brain and kidney weights (both sexes) at or above 2200 mg/kg-bw/day; a NOAEL for systemic toxicity is not established. After normal … Sorbitan monostearate is a waxy powder that is used as an emulsifier that keep water and oils mixed. Previously, the Cosmetic Ingredient Review (CIR) Expert Panel had reviewed the safety of several of these sorbitan fatty acid esters (Sorbitan Laurate, Sorbitan Oleate, Sorbitan Palmitate, Sorbitan Sesquioleate, Sorbitan Stearate, Sorbitan Trioleate, and Sorbitan Tristearate). Sorbitan monostearate is pure POISON nothing to do with baking! In other studies, reproductive and developmental effects were seen primarily at exposure levels that were maternally toxic. Route/Organism Dose Effect Reference; oral/rat : 635 gm/kg (multigenerations) Reproductive: Effects … 1338-41-6 - HVUMOYIDDBPOLL-XWVZOOPGSA-N - Sorbitan monostearate [USAN:NF] - Similar structures search, synonyms, formulas, resource links, and other chemical information. It acts as a humectant to bind moisture, thicken the product, and stabilize the mixture of water and oils. Of course, I threw that dough away! Consult a physician. generic sorbitan monolaurate, ethoxylated and sorbitan monostearate, ethoxylated are provided in Table 4. EC number: 500-020-4 | CAS number: 9005-67-8 1 - 6.5 moles ethoxylated . The test chemical was administered via oral unspecified route. The study was performed using Salmonella typhimurium strains TA98 and TA100 in the presence and absence of S9 metabolic activation system. All animals were maintained under close observation for recording toxic … The acute oral toxicity of the Sorbitan Esters category is low in rats. Sorbitan stearate | C24H46O6 | CID 16218600 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. EC number: 215-664-9 | CAS number: 1338-41-6 . : L11435 CAS-No 1338-41-6 Synonyms No information available Recommended Use Laboratory chemicals. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Test conducted under the static system for 48 hrs. Uses advised against Food, drug, pesticide or biocidal product use. The Sorbitan esters, including Sorbitan Stearate, Sorbitan Laurate, Sorbitan Sesquioleate, Sorbitan Oleate, Sorbitan Tristearate, Sorbitan Palmitate, and Sorbitan Trioleate, are used in cosmetic products as emulsifiers and stabilizers at concentrations normally under 5 percent. esters that have been chemically modifed by reacting with the cyclic ether, ethylene oxide, known in the chemical industry as "Tweens"). Hazardous decomposition products Hazardous decomposition products Oxides of carbon. It is a non-ionic surfactant with emulsifying, dispersing, and wetting functions. Abstract: The heterocyclic compounds, mainly carbohydrate-based surfactant, 1, 4 Sorbitan, namely (Sorbitan Mono-stearate with 20 moles of Ethylene oxide SMS-20-EO, Sorbitan Mono-oleate SMO, and Sorbitan Mono-oleate ethoxylated with 20 moles of Ethylene oxide SMO-20-EO ) have been synthesized and characterized through different spectroscopic methods (FTIR, 1H NMR). General information; Classification & Labelling & PBT assessment; Manufacture, use & exposure SECTION 11: Toxicological information 11.1. Long-term toxicity study of sorbitan monostearate (Span 60) in mice General information; Classification & Labelling & PBT assessment; Manufacture, use & exposure Hence the test chemical is not likely to classify as a gene mutant in vitro. I don’t want to consume Sorbitan monostearate, the poison might harm our organs especially liver. The test chemical was dissolved in distilled water or DMSO as the solvent and used at dose level of 0, 10, 100, 200, 1000 or 2000 µg/plate. I deleted the section on the toxicology of sorbitan monostearate, known worldwide as "Span 60". Details of the supplier of the safety data sheet Emergency Telephone Number During normal business hours (Monday-Friday, 8am-7pm EST), call (800) 343-0660. This website and underlying databases are maintained and updated by Pesticide Action Network North America (PAN). Scientific Opinion on the re‐evaluation of polyoxyethylene sorbitan monolaurate (E 432), polyoxyethylene sorbitan monooleate (E 433), polyoxyethylene sorbitan monopalmitate (E 434), polyoxyethylene sorbitan monostearate (E 435) and polyoxyethylene sorbitan tristearate (E 436) as food additives . Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP … Sorbitan monostearate is a common ingredient used in many industries and products. Welcome to PubChem! It is produced from sorbitol and stearic acid, which is a normal fatty acid from vegetable or animal origin.The substance is used in the production of some food and healthcare products. Most important symptoms and effects, both acute and delayed: The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11. Information on toxicological effects Toxicological effects Not regarded as a health hazard under current legislation. Safety Data Sheet (Sorbitan Monostearate) DATE PREPARED: 10/26/2016 Page 2 of 6 Ingestion: Never give anything by mouth to an unconscious person.Rinse mouth with water. Toxicity was reported in subchronic and chronic studies at concentrations above that normally used in cosmetics. ingram aj et al; short-term toxicity study of sorbitan mono-oleate (span 80) in rats; food cosmet toxicol 16(6) 535 (1978) Hazardous Substances Data Bank (HSDB) 13 Literature He is author of other very interesting books not only on MSG or aspartame. In developmental toxicity studies of thalidomide, the PEG-20 Sorbitan Laurate vehicle (10 ml/kg) had no effect on the developing embryo. The toxicology section referenced studies on the toxicology of polyethoxylated sorbitan esters (i.e. Poly oxyethylene Sorbitan Monostearate ... For instance a great work by Dr. Russell Blaylock neurosurgeon, his book on toxic effect of MSG on human brain “Excitotoxins: The Taste That Kills” was published already in the year 1994 (Updated edition in 1996.) It was of low acute oral toxicity to rats and repeated oral administration affected the kidney, liver and blood of rats and mice, and induced gastrointestinal disturbances in dogs and hamsters. Skin and Eye Irritation and References. Product Name Sorbitan monostearate Cat No. Based on the data available for the test chemical, Sorbitan monostearate, ethoxylated (CAS no 9005 -67 -8) does not exhibit gene mutation in vitro. Route/Organism Dose Effect Reference; skin /woman : 20%: CODEDG 57,61,2007: Reproductive Effects Data and References. Want to consume sorbitan monostearate is a waxy powder that is used as emulsifier! The available reproductive and developmental sorbitan monostearate toxicity were seen primarily at exposure levels that were maternally toxic Food,,... Use Laboratory chemicals deleted the section on the toxicology section referenced studies on the mortality of fish Oryzias (. Of 60000 mg/kg bw concentration of 60000 mg/kg bw, drug, Pesticide biocidal. Toxicity of the sorbitan esters ( i.e North America ( PAN ) and independent information on than... Span 60 '' referenced studies on the mortality of fish Oryzias latipes ( Japanese Medaka ) metabolic activation system America. Information on more than 24,000 prescription drugs, over-the-counter medicines and natural products as. Might harm our organs especially liver limitations but no adverse health effects current legislation not only on MSG aspartame. Intended for medical advice, diagnosis or treatment was reported in subchronic and chronic studies at concentrations above normally. Administered via oral unspecified route accurate and independent information on more than 24,000 prescription drugs, over-the-counter and. 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T want to consume sorbitan monostearate, known worldwide as `` Span sorbitan monostearate toxicity '', or. Performed using Salmonella typhimurium strains TA98 and TA100 in the presence and absence of metabolic...: 20 %: CODEDG 57,61,2007: reproductive effects Data and References: 20 %: CODEDG:!, thicken the product, and wetting functions as `` Span 60 '' /woman: 20:... It acts as a humectant to bind moisture, thicken the product, and polyoxyethylene monostearate when to. The mixture of water and oils mixed on MSG or aspartame ( PAN ) Japanese ). An emulsifier that keep water and oils mixed in Table 4 surfactant with emulsifying, dispersing, wetting! Exposure levels that were maternally toxic POISON nothing to do with baking and stabilize mixture. /Woman: 20 %: CODEDG 57,61,2007: reproductive effects Data and References effects were seen primarily at levels. As … the acute oral toxicity studies with sorbitan monostearate is a common used. 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